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Mrunalini, Miriyala
- Formulation and Evaluation of Sustained Release Stavudine Microspheres by Ionotropic Gelation Method
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Affiliations
1 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
2 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
3 Department of Chemistry, Vijaya Teja Degree College, Addanki - 523201, Andhra Pradesh, IN
1 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
2 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
3 Department of Chemistry, Vijaya Teja Degree College, Addanki - 523201, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 2 (2022), Pagination: 119-124Abstract
As a novel drug delivery system, microspheres improve the efficacy of a drug, increase the time of action, lower the number of times in which a dosage form needs to be administered, and to increase patient compliance. Oral administration side effects such as gastric irritation are lessened through the use of microspheres. Ionotropic gelation was used to create HPMC K15M, Guar gum, and Carbopol 934 microspheres with different concentrations of Carbopol 934 polymer. Cross-linking was accomplished with the use of calcium chloride. In order to conduct a systematic evaluation of all the preparations, we performed various tests: morphology, FTIR, DSC, entrapment efficiency, size, microsphere size, and in-vitro drug release. The discrete, free-flowing, and spherical particles of prepared Stavudine microspheres were found. In compliance with standards, the mean particle size was in the range of 72.64 to 95.22 percent. In vitro drug release studies were performed in phosphate buffer solution with a pH of 6.8. As the concentration of sodium alginate and calcium chloride increased, the percentage of drug release was reduced. In the case of F9 formulation, which contained Stavudine, the decreased drug release rate was obtained via carbopol 934(1:3), sodium alginate, and calcium chloride. Conclusively, the present study shows that Stavudine microsphere preparation and formulation F9 are successful. Stavudine microspheres must be prepared in order to preserve an effective drug concentration in serum for a long time, while reducing gastrointestinal irritation.Keywords
Microspheres, Controlled Release, Stavudine, In-vitro Studies
References
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- Design, Formulation and Evaluation of Fexofenadine HCl Immediate Release Tablets by Solid Dispersion Method using Solvent Evaporation Technique
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Authors
Affiliations
1 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
2 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
3 Department of Chemistry, Vijaya Teja Degree College, Addanki, Andhra Pradesh, IN
1 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
2 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
3 Department of Chemistry, Vijaya Teja Degree College, Addanki, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 4 (2022), Pagination: 290-298Abstract
Currently, this study focuses on developing immediate-release Fexofenadine hydrochloride tablets. The Fexofenadine HCl tablets have super disintegrants that help to accelerate dissolution and bioavailability. Sodium lauryl sulphate, microcrystalline cellulose as filler, crospovidone, and sodium starch glycolate were used to make the tablets using a direct compression method (2-8 percent). Pre and post compressional parameters were used in the preparation of the tablets. The In-vitro disintegration study shows that as concentration of sodium starch glycolate is increased, there is an increase in the amount of time it takes for the solution to disintegrate, but at the same time, there is a decrease in the amount of time it takes for the solution to disintegrate when the crospovidone level is increased. When combined with the crospovidone tablet formulation, the test found that the resulting tablets broke down in approximately 3 to 6 minutes, with enough force to release the fragments but not to harm the friability of the product. It was found that Fexofenadine hydrochloride tablet, a fast-acting form of treatment for allergic rhinitis, could be formulated in an immediate-release form.Keywords
Allergic Rhinitis, Crospovidone, Croscarmellose SodiumReferences
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- Synthesis, characterization, anti-inflammatory and anti-oxidant activities of novel 2, 4-di substituted 1, 5- benzodiazepine derivatives
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
2 Department of Chemistry, Vijaya Teja Degree College, Addanki-523201, Andhra Pradesh ., IN
3 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh ., IN
4 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
5 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
1 Department of Pharmaceutical Chemistry, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
2 Department of Chemistry, Vijaya Teja Degree College, Addanki-523201, Andhra Pradesh ., IN
3 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh ., IN
4 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
5 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
Source
Asian Journal of Research in Chemistry, Vol 15, No 2 (2022), Pagination: 109 - 114Abstract
The study's goal is to synthesis novel benzodiazepine analogues, some of which are chalcones. The elemental analysis, infrared, and 1H nuclear magnetic resonance examinations examined the structures of the newly produced substances. To test for anti-inflammatory and anti-oxidant properties, all substances bearing a descriptor were evaluated. Here, 1,5-(disubstituted phenyl)-2,4-pentadien-1-one derivatives are created from scratch using a new process. By condensing cinnamaldehyde with different aromatic ketones in the presence of 10% NaOH as a base, 1,5-(disubstituted phenyl)-2,4-pentadien-1-one was produced. 2-(substituted phenyl)-3- styryl-2,3-dihydro-1H-benzodiazepine derivatives were synthesised from 1,5-(disubstituted phenyl)-2,4- pentadien-1-one on cyclization with o-phenylene diamine in the presence of NaOH as base. Carrageenan and formalin-induced rat paw edoema technique was used to evaluate the antioxidant and anti-inflammatory activities of the final synthesised benzodiazepine derivatives. Compared to the usual ascorbic acid and diclofenac sodium, the compounds displayed significant anti-inflammatory effect. This means that nitro, chloro, fluoro, and bromo included electron withdrawing groups, which caused an increase in anti-inflammatory action. Most of the produced drugs had strong anti-inflammatory efficacy .Keywords
Chalcones, 1,5-benzodiazepines, Anti-inflammatory activity, Anti-oxidant activity.References
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